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If your question is already answered in FAQ or on forum, we invite you to view this topic or ask your question again.Tissue oxygenation during local cooling.
During a single-pass hypercapnic challenge, an artificial perfusion circuit was used to examine the local effects of 3 degrees C surface skin cooling on tissue pH, oxygenation, and oxygen extraction. In the 10 volunteers, left external jugular vein blood and deep tissue (vastus lateralis) and left calf blood were sampled from the femoral artery, and pulmonary arterial blood was simultaneously sampled from the right internal jugular vein. A venous inflow cannula was placed in the superficial vein and was connected via a Y-piece to a bilateral femoral artery and right internal jugular vein line, in a closed-circuit system. The left calf muscle was simultaneously cooled for 30 minutes to 3 degrees C. Venous and arterial pH and carbon dioxide tension were unaltered at the end of this period. Arterial and deep tissue oxygen tension decreased in all subjects. In contrast, venous oxygen tension in the femoral vein increased. Regional oxygen extraction decreased from 12.5 +/- 4.1% during the control study (mean +/- SD) to 9.1 +/- 3.7%, P =.001. The decrease in arterial oxygenation during cooling was associated with an increase in oxygen extraction, suggesting an adaptive hyperoxia to maintain oxygen delivery to skeletal muscle at rest.Modulation of experimental aortic aneurysms by interleukin 1 receptor blockade.
Inflammatory processes such as macrophage accumulation and activation are involved in the pathogenesis of abdominal aortic aneurysm (AAA). The present study examines the effects of interleukin 1 receptor blockade on experimental AAA. An elastase-induced model of AAA was used. Aortic diameter was measured on a weekly basis in rats injected with either normal saline or 10 microg/kg of recombinant interleukin 1 receptor antagonist (IRAP) for 12 wk starting on the day of elastase injection. Apoptosis in the aorta was examined with the TUNEL technique. In another set of studies, aortas of each group were subjected to a histologic analysis
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